Intraventricular Neurocysticercosis and Bruns' Syndrome: A Review
Breanna R Campbell, David Reynoso, and A Clinton White Jr*
Infectious Disease Division, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA
Neurocysticercosis, caused by Taenia solium, is a common cause of neurologic disease worldwide. Approximately 2,000 cases per year are diagnosed in the United States. Intraventricular neurocysticercosis is a severe form of the disease, in which cysticerci within the cerebral ventricles cause obstructive hydrocephalus. Symptoms of hydrocephalus include headache, nausea, vomiting, altered mental status, dizziness, and decreased visual acuity. In some cases, sudden onset of symptoms are associated with changes in head position leading to acute obstruction (Bruns’ syndrome). Diagnosis depends on neuroimaging studies, especially 3 dimensional MRI sequences. Optimal treatment involves relief of hydrocephalus by removal of the cysticerci. For cysticerci in the lateral and third ventricles, this can usually be accomplished via minimally invasive surgery (neuroendoscopy). However, this is not possible with adherent cysticerci. In some cases of cysticerci in the 4th ventricle, open surgical microdissection via an occipital approach may be safer. Mortality is rare with appropriate management.
Cysticercosis refers to infection by the larval stage of the pork tapeworm Taenia solium, whose clinical manifestations include neurocysticercosis (NCC) and extraneural cysticercosis. NCC is divided into parenchymal and extraparenchymal forms; the latter includes intraventricular, subarachnoid, and occasionally spinal. Intraventricular NCC (IVNCC) can be rapidly progressive and fatal if untreated. There is an emerging consensus in the literature for treatment of IVNCC. Here we review the epidemiology, presentation, diagnosis, and current management recommendations of IVNCC.
NCC is the most common helminthic neurological infection in the world, and one of the most frequent causes of adult-onset epilepsy and hydrocephalus worldwide1 Globally, NCC is reported to affect approximately 50 million individuals, mainly in Latin America, sub-Saharan Africa, and South and Southeast Asia2. A meta-analysis noted that 29% of people with epilepsy in areas endemic to T. solium have NCC3. Given the limited availability of advanced diagnostic imaging modalities in endemic areas, infection prevalence is likely underestimated2.
Based on reviews of a national sample of discharge summaries for the years 2003-2015, there were estimated to be over 18000 U.S. hospitalizations for NCC, leading to a healthcare cost greater than USD $900 million4, with 1320-5050 new cases diagnosed per year5.
Parasite life cycle
T. solium infects pigs as intermediate hosts, with humans serving as both intermediate and definitive hosts. When a person eats undercooked pork meat containing a viable cysticercus, the larval stage of T. solium, the scolex evaginates, and the suckers and hooks of the scolex attach to the intestinal mucosa. The ensuing maturation and intestinal infestation by adult tapeworms is known as taeniasis, and is characterized by largely-asymptomatic shedding of large numbers of proglottids and eggs in stool6. Pigs acquire cysticercosis by ingesting eggs or proglottids shed by the tapeworm carrier. Humans also acquire cysticercosis by ingesting the T. solium eggs via autoinfection or from another human carrier of tapeworm eggs. After ingestion, the eggs hatch and release the invasive larvae (termed oncospheres); these invade the intestinal wall and spread through the bloodstream. While cysticerci may develop in a wide range of organs, most symptomatic disease results from infection of the central nervous system, subcutaneous tissue, and eyes6.
Most patients with neurocysticercosis present with cystic lesions or calcifications in the brain parenchyma. Seizures are the most common presenting symptom of parenchymal NCC1. In contrast, the main presentation of IVNCC or subarachnoid NCC is with symptoms of raised intracranial pressure such as headache, nausea, vomiting, or dizziness6. Extraparenchymal NCC refers to involvement of the ventricles, subarachnoid space, and occasionally the spine; mixed forms are common. Subarachnoid disease often involves the basilar cisterns and Sylvian fissures. In some cases, the parasites transform into proliferating membranes termed racemose cysticercosis. In spinal NCC, the leptomeningeal spaces are frequently involved, and cysts may inhabit the spinal cord itself. Spinal involvement was previously considered rare, but appears to be seen frequently in patients with basal subarachnoid NCC7. Subarachnoid NCC may present with a range of clinical manifestations including communicating hydrocephalus, mass lesions, stroke, and meningismus1.
IVNCC is the presenting form of NCC in approximately 10-20% of patients worldwide6. Most often, extraparenchymal NCC presents with symptoms of hydrocephalus, carrying a high mortality rate1. In the U.S., approximately 16% of NCC cases present with hydrocephalus8. A review of inpatient cysticercosis deaths from 1998 to 2011 found obstructive hydrocephalus in 27% of deaths9. When viable, the cysts are often freely mobile and may lodge in foramina or the aqueduct. The resulting mechanical obstruction is the most frequent cause of hydrocephalus, whether occurring at the ventricles; the aqueduct of Sylvius; or the foramina of Monro, Luschka, or Magendie.
Hydrocephalus typically presents with headache, nausea, vomiting, altered mental status, and decreased visual acuity associated with papilledema6. Acute hydrocephalus can lead to sudden death by brainstem herniation, displacement, or distortion10; or may present strikingly in the form of Bruns’ syndrome, with sudden attacks of severe headache, nausea/vomiting, and vertigo, brought on by abrupt head movement11. This constellation of symptoms is due to episodic hydrocephalus related to intermitted obstruction of cerebrospinal fluid (CSF) flow by ball-valve movement of intraventricular cysts. Bruns syndrome was originally described in fourth ventricular NCC, but can also be caused by third ventricular cysts, tumors12, or even tuberculomas13.
Diagnosis of NCC can be difficult; in IVNCC, diagnosis is usually straightforward and based primarily on imaging studies with confirmation from serologic tests.
A number of serologic tests are available for the diagnosis of neurocysticercosis. Most tests employing crude antigens (including all commercially available ELISAs) are associated with poor sensitivity and specificity. The only reliable test for antibody in cysticercosis is the enzyme-linked immunotransfer blot (EITB) assay. While the sensitivity is not optimal for single parenchymal cysticeri or for calcified disease, the sensitivity and specificity of EITB are close to 100% for IVNCC14. EITB carries a greater sensitivity on serum samples as compared to CSF samples (100% to 85.7-90.2%, respectively)15. Therefore, there is essentially no advantage to using CSF for EITB assays.
Non-contrast CT scanning is sensitive for calcified and parenchymal lesions, but is insensitive for extraparenchymal disease15. Thus, MRI is the preferred diagnostic test for extraparenchymal NCC (Figure 1). On either CT or MRI, viable cysticerci are small and round, with thin walls and fluid isodense to CSF. T1 sequences may reveal a dense nodule within the cyst (“hole-in-dot”). Given the complementary nature of CT and MRI with regard to NCC, both modalities are recommended for diagnosis. A study on the role of conventional MR imaging sequences in the evaluation of NCC found that a T1-gadolinium series acquired 8 minutes after contrast injection was more specific for total NCC lesions than fluid attenuation inversion recovery (FLAIR), T1 and T2 series, and early T1-gadolinium images16. Gadolinium-enhanced MRI (Gd-MRI) may aid in detecting ependymitis17, a relative contraindication to neuroendoscopy18. However, Gd-MRI is not proven to characterize subarachnoid or intraventricular NCC, as these cysts have similar signal intensity to CSF16.
Figure 1: Sagittal view T1 (a) and T2 (b) images from a patient with neurocysticercosis involving the (a.) 3rd ventricle, basilar cisterns, and (b.) parenchyma.
Newer MRI acquisition techniques promise improved detection of IVNCC, including fast imaging employing steady-state acquisition (FIESTA), three-dimensional constructive interference in steady state (3D CISS; a modified FIESTA sequence), T2 star-weighted angiography (SWAN), and spoiled gradient recalled echo sequence (SPGR). Thus far, FIESTA and SPGR have demonstrated the best sensitivity in detecting IVNCC19. FIESTA is more sensitive than SPGR in demonstrating the cysticercus membrane in subarachnoid NCC, while FLAIR is more sensitive than T2 (but not T1) SPGR20. Similarly, SWAN has demonstrated improved detection of IVNCC as compared to traditional MRI21. Further, 3D CISS has been used to diagnose previously missed obstructive membranes in IVNCC22.
Treatment of neurocysticercosis includes managing hydrocephalus, seizures, and the infection itself. Initial attention to life threatening symptoms is imperative, most notably increased intracranial pressure (ICP). While there may be benefit to anti-inflammatory therapy such as steroids in some cases, neurosurgical intervention is key in patients with increased ICP1. Antiparasitic therapy designed to eliminate the infection is never an emergency, and is contraindicated in the setting of increased ICP15.
Neuroendoscopy and minimally invasive approaches
The traditional approach for increased ICP related to IVNCC is placement of an external ventricular drain (EVD) or ventriculoperitoneal shunt (VPS) to relieve pressure. However, shunt failure is common, and mortality in these cases remains high1. Furthermore, relief of hydrocephalus via EVD or VPS may make definitive therapy by neuroendoscopy more difficult. Antihelminthics may decrease the rate of shunt failure, but should not be given if cyst removal is planned15.When possible, cyst removal is the mainstay of management of IVNCC with obstructive hydrocephalus. Neuroendoscopy is now considered the primary procedure for relief of IVNCC-related hydrocephalus. Under direct endoscopic visualization, cystercerci appear as a “full moon:” this endoscopic sign is considered pathognomonic for IVNCC. Even in the emergent case of Bruns’ syndrome, neuroendoscopy has been proven both diagnostic and curative23, though it occasionally requires endoscopic third ventriculostomy (ETV) or septum pellucidotomy to treat hydrocephalus24,25. These approaches require a practiced hand and are not without their risks, which include intraventricular bleeding26, memory loss, hemiparesis, mutism, and aphasia24. It should be noted that multiple studies wherein cysts have ruptured during endoscopy have not been complicated by subsequent development of ventriculitis or arachnoiditis27. Finally, antiparasitic therapy after IVNCC cyst excision may not be necessary. A systematic review found that patients who underwent surgical removal of a single intraventricular cyst and received antiparasitic therapy afterward had a lower rate of delayed hydrocephalus than those who did not27, but a large case series from the NIH has not confirmed this finding28.
Fourth ventricle Neuroendoscopy and open surgery
While the fourth ventricle is a common site of IVNCC, reports of successful flexible neuroendoscopy for fourth ventricle extirpation are limited compared to that of lateral or third ventricles. Transventricular, transforaminal flexible endoscopy and transventricular, transaqueductal scope-in-scope endoscopy have proven effective in extirpation of fourth ventricle cysts10,18,29. Endoscopy was performed in conjunction with ETV in these cases, and shunt placement was avoided in each patient. However, both involve passage of the scope through the aqueduct, which poses risks for major neurologic damage. Open surgical microdissection for fourth ventricular NCC requires suboccipital craniotomy, but is generally well tolerated. However, compared to endoscopic approaches, open surgery may lead to increased operative time, blood loss, and hospitalization24, and delayed hydrocephalus commonly occurs30.
Cyst death releases antigenic material into the ventricles, leading to ventriculitis31. Localized reactions may then fixate the cyst capsules to the walls of the ventricles or to the subarachnoid tissue, causing adherent cysticerci (Figure 2). These, in turn, may also block CSF flow and predispose the patient to sustained hydrocephalus and elevated ICP. In such cases, surgical involvement is usually not possible without causing damage to nearby structures32. Instead, patients should be managed by CSF diversion without cyst extirpation18,32, although partial resection via flexible neuroendoscopy with additional ETV has proven successful29.
Figure 2: T1 MRI demonstrating a degenerating cyst adherent to the wall of the 4th ventricle.
Neurocysticercosis presents with a pleomorphic clinical picture including potentially fatal intraventricular neurocysticercosis, which usually presents with symptoms of obstructive hydrocephalus. Advanced MRI imaging modalities improve the sensitivity of diagnosis of IVNCC and aid in guiding intervention. Flexible neuroendoscopy has emerged as the surgical approach of choice when possible. Adoption of neuroendoscopy as an initial and primary intervention for treatment of IVNCC is likely to improve outcomes for patients suffering from this disease. However, many neurosurgeons prefer open microdissection for cysticerci in the fourth ventricle. Adherent cysticerci often cannot be removed; patients instead require shunting for relief of obstructive hydrocephalus, followed by steroids and antiparasitic drugs to lessen the risk of shunt failure.
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